Controlling complex networks has recently been of great interests. In a controlled network, a steering node is a node on which an independent control signal is actuated. Currently the main issue of network control is to find a minimum set of steering nodes (MSS) required to have a network fully controllable. This issue can be efficiently addressed by some graph-theoretic algorithms. On the other hand, drug targets can be modelled as steering nodes in a bionetwork, which combine with drugs (control signals) are expected to steer a disease phenotype to a healthy phenotype. However, it is well known that MSS is not unique and that most MSSs of a bionetwork are not meaningful from biological point of view, which are problematic in applications.In this talk, after reviewing necessary background about complex network controllability, I will present some of our recent research results in finding the meaningful MSS in biomolecular networks and its applications to drug target identification.
Dr. FangXiang Wuis a full professor of College of Engineering and of Department of Computer Science at the University of Saskatchewan, Canada. Since 2016, Dr. Wu has become a national "1000 plan" guest professor at Central South University, Changsha, China. Dr. Wu received the B. Sc. degree and the M. Sc. degree in Applied Mathematics, both from Dalian University of Technology, Dalian, China, in 1990 and 1993, respectively, the first Ph.D. in Control Theory and Its Applications from Northwestern Polytechnical University, Xi’an, China, in 1998, and the second Ph.D. in Bioinformatics and Systems Biology from University of Saskatchewan, Saskatoon, Canada, in 2004. He worked as a postdoctoral fellow with Laval University Medical Research Center, Quebec City, Quebec, during 2004-2005. His current research interests are in Bioinformatics and computational network biology, including Complex network controllability and applications, Biomolecular network analytics, Machine learning in bioinformatics, Biological data analytics, Brain images and brain networks, and Nonlinear biodynamic analytics.He has published about 200 refereed journal papers and over 100 refereed conference papers. He has been invited to deliver about 60 academic talks in the international conferences and academic institutes all over the world. Wu has served as the editorial board member/associate editor of five international journals (Scientific Reports, Neurocomputing, etc.), as the guest editor of over 20 international journals, and as the program committee chair or member of more than 30 international conferences.
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